Partner Institutes
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Queen Mary, University of London | National Health Research Complex, Lahore |
Project brief:
The real tragedy is that her condition could have easily been prevented. Congenital hypothyroidism is among several metabolic disorders present at birth that can lead to growth failure and mental retardation. In the developed world, one in every 4000 babies are born with congenital hypothyroidism. But because treatment is so simple and inexpensive, all babies are screened at birth and are treated within one month, to prevent them for being mentally retarded.
The collaboration between Queen Mary, University of London and the
National Health Research Complex, Lahore under the INSPIRE banner aims to start
and strengthen newborn screening programmes to avoid late diagnosis of
congenital disorders that result in unnecessary health and economic burdens for
the country and emotional trauma for the family.
Imported systems of screening are very expensive and local hospitals, with their already stretched budgets, do not place great importance on acquiring them. This project plans to develop testing kits locally to make the process of newborn screening inexpensive and accessible to all hospitals across Pakistan. A centralised screening lab has already been established, where blood spot samples are being screened from different hospitals.
National
and international in-job technologists, researchers and post-graduate students
are also using the facility of this lab, which has been equipped by the
donation of the UK link coordinator, the late Dr. Raymond Edwards.
A very important aspect
of the collaboration is to create awareness amongst local communities about
congenital disorders so that early screening and diagnosis can be made
possible. The project team has carried out awareness campaigns that highlight
how simple it is to treat the condition if it is revealed in time. A daily dose of the hormone thyroxin is
all that is required to prevent more Wardahs from feeling like they don’t
belong.
Lessons learnt:
The collaboration
of Pakistani researchers with labs in the UK has given them the opportunity to
broaden their vision, and to learn modern techniques for transfer of
technology. They have also learnt to develop reagents at affordable costs for
diagnostic use.
Challenges faced:
- Convincing local hospital authorities to implement the screening programme.
- Difficulty in procuring one of the reagents (the detecting antibody).
The impacts/benefits of the project
- Locally developed reagents would be available for establishing a nationwide screening programme.
- A screening programme for congenital hypothyroidism would be available at an affordable cost and save Pakistan valuable foreign exchange.
- Newborns could be saved from being mentally handicapped.
- More screening tests could be developed using the same technology. Further research could be carried out at an affordable cost.
Key
contacts:
Prof
David Perrett, Queen Mary, University of London
Farkhanda Ghafoor, National Health Research Complex
fghafoor99@hotmail.com, www.pmrc.org.pk/nhrc.htm